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Anti-Mouse CD120b (TNFR2) [TR75-54.7] – DyLight® 488 - 100 µg

Anti-Mouse CD120b (TNFR2) [TR75-54.7] – DyLight® 488 - 100 µg

Item no.	LEIN-T627-100ug
Manufacturer	Leinco Technologies
Amount	100 ug
Quantity options	100 ug 200 ug 50 ug
Category	Antibodies Flow Cytometry Primary Antibodies
Type	Antibody Monoclonal
Applications	FC
Clone	TR75-54.7
Specific against	Mouse (Murine, Mus musculus)
Host	Hamster - Armenian
Citations	1. Zuckerman, KS. et al. (1998) Cancer Res. 58: 2217 2. Chan, FKM. et al. (2000) Science 288:2351 3. Loetscher, H. et al. (1990) Cell 61:351 4. Rothe, J. et al. (1993) Nature 364:798
NCBI	21938
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Shipping Condition	Cool pack
Available
Manufacturer - Category	Primary Monoclonal Antibodies>Apoptosis & Cell Biology
Manufacturer - Targets	TNFR2
Country of Origin	USA
Shipping Temperature	Next Day 2 - 8°C
Storage Conditions	This DyLight® 488 conjugate is stable when stored at 2-8°C. Do not freeze.
Product Description	Tumor necrosis factor receptor II (TNF-RII) or CD120b is a 75kD type I transmembrane protein present on most cell types at low levels1 including endothelial cells, cardiac myocytes and prostate cells2; the expression is upregulated upon activation. This receptor binds both TNF-α & TNF-β (aka. LT-α). In association with TRAF1 and TRAF2, the receptor crosslinking induced by TNF-α or LT-α trimers is critical for signal transduction, leading to apoptosis, NF-kB activation, increased expression of proinflammatory genes, tumor necrosis, and cell differentiation depending on cell type and differentiation state. The TR75-54.7 antibody has been shown to block ligand-induced receptor signaling.
Background	Tumor necrosis factor receptor II (TNF-RII) or CD120b is a 75kD type I transmembrane protein present on most cell types at low levels¹ including endothelial cells, cardiac myocytes and prostate cells²; the expression is upregulated upon activation. This receptor binds both TNF-α & TNF-β (aka. LT-α). In association with TRAF1 and TRAF2, the receptor crosslinking induced by TNF-α or LT-α trimers is critical for signal transduction, leading to apoptosis, NF-kB activation, increased expression of proinflammatory genes, tumor necrosis, and cell differentiation depending on cell type and differentiation state. The TR75-54.7 antibody has been shown to block ligand-induced receptor signaling.
PubMed	TNFR2
Excitation Laser	Blue Laser (493 nm)
Manufacturer - Research Area	Immunology, Innate Immunity
Manufacturer - Specificity	Armenian Hamster Anti-Mouse Tumor Necrosis Factor Receptor II (TNF RII) (Clone TR75-54.7) recognizes an epitope on Mouse TNF RII. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
RRID	AB_2832074
Concentration	0.2 mg/ml
Formulation	This DyLight® 488 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Immunogen	E. coli -expressed mouse Type II TNFR
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Monoclonal Antibody, Tumor Necrosis Factor Receptor II, TNFRSF1B, p75, CD120b, TBPII, TNF-R75, TNFBR, TNFR2, TNFR80, p75TNFR, TR75-54.7, TNF RII, Mouse CD120b, Anti-Mouse TNF RII

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-T627-100ug-safety-datasheet.pdf