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Anti-West Nile Virus Core (NT) (WNV Core) - 0.1 mg

Anti-West Nile Virus Core (NT) (WNV Core) - 0.1 mg

Item no.	LEIN-W143-0.1mg
Manufacturer	Leinco Technologies
Amount	0.1 mg
Quantity options	0.1 mg 20 ug
Category	Antibodies ELISA Primary Antibodies Immunostaining
Type	Antibody Primary
Applications	ELISA
Specific against	Virus
Host	Rabbit
Citations	1. Gould, L. H. et al. (2004) J. Clin. Invest. 113:1102 2. Chu, J. J. et al. (2005) J. Gen. Virol. 86:405 3. Chu, J. J. et al. (2004) J. Biol. Chem. 279:54533 4. Yang, J. S. et al. (2002) Emerg. Infect. Dis. 8:1379
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Applications	ELISA Indirect
Manufacturer - Category	Primary Monoclonal Antibodies>Infectious Diseases
Manufacturer - Targets	West Nile Virus Core
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Product Description	West Nile Virus (WNV) is a member of the Flaviviridae, a plus-stranded virus family that includes St. Louis encephalitis virus, yellow fever virus, and Dengue virus. WNV was initially isolated in 1937 in the West Nile region of Uganda and has become prevalent in Africa, Asia, and Europe. It has rapidly spread across the United States with cases being observed in every continental state (reviewed in 1). Virus particles consist of a dense core made up of the core/capsid protein encapsulating the RNA genome surrounded by a membrane envelope embedded with envelope and matrix proteins1 which play a major role for WNV entry into target cells.2, 3 The viral core protein is thought to contribute to the WNV-associated inflammation via apoptosis induced though the caspase-9 pathway as delivery of core gene delivery into the striatum of mouse brain and skeletal muscle resulted in cell death and inflammation.4
Background	West Nile Virus (WNV) is a member of the Flaviviridae, a plus-stranded virus family that includes St. Louis encephalitis virus, yellow fever virus, and Dengue virus. WNV was initially isolated in 1937 in the West Nile region of Uganda and has become prevalent in Africa, Asia, and Europe. It has rapidly spread across the United States with cases being observed in every continental state (reviewed in 1). Virus particles consist of a dense core made up of the core/capsid protein encapsulating the RNA genome surrounded by a membrane envelope embedded with envelope and matrix proteins¹ which play a major role for WNV entry into target cells.^{2, 3} The viral core protein is thought to contribute to the WNV-associated inflammation via apoptosis induced though the caspase-9 pathway as delivery of core gene delivery into the striatum of mouse brain and skeletal muscle resulted in cell death and inflammation.⁴
PubMed	West Nile Virus Core
Manufacturer - Research Area	Category B Pathogens, Infectious Disease, Viral, West Nile, IVD Raw Material
Manufacturer - Specificity	Rabbit Anti-West Nile Virus Core (WNV Core) recognizes an epitope near the N-terminus of WNV Core. This polyclonal antibody was purified using affinity chromatography.
RRID	AB_2832176
Concentration	0.5 mg/ml
Formulation	This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	WNV Core Antibody, Genome polyprotein, Core protein, NS1

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LEIN-W143-0.1mg-safety-datasheet.pdf