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CD130 monoclonal antibody

CD130 monoclonal antibody

Manufacturer	Bioworld Technology, Inc
Category	Neuroscience Neural Lineage Markers Neuroinflammation Metabolism Diabetes Glucose Homeostasis Molecular Targets for Neuroscience Antibodies Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Immunohistochemistry Western Blot Immunocytochemistry Primary Antibodies Glial Cell Markers
Type	Antibody Primary
Specific against	Human
Applications	WB, IHC, ICC
Amount	100ul
Host	Mouse
Item no.	MB9126-100
Targets	IL6 ;; OSM ;;CD126;;CD130;;IL6R;;IL6ST;;OSMR;;THBS1
eClass 6.1	32160702
eClass 9.0	32160702
Available
Swiss-Prot	P40189(Human)
Application_all	WB:1:500-1:2, 000 ICC:1:50-1:200 IHC:1:50-1:200
Background	Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases. That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3. Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism. Has a role in embryonic development. Does not bind IL6. Essential for survival of motor and sensory neurons and for differentiation of astrocytes. Required for expression of TRPA1 in nociceptive neurons. Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation. Required for normal trabecular bone mass and cortical bone composition.
Product	Mouse IgG2b, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification And Purity	ProG affinity purified
Storage And Stability	Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Specificity	CD130 monoclonal antibody detects endogenous levels of CD130 protein.
BiowMW	103 kDa
Note	For research use only, not for use in diagnostic procedure.
Immunogen	Recombinant protein

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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