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Human Crystallin alpha A/CRYAA antibody

Human Crystallin alpha A/CRYAA antibody

Item no.	NKM-ACA0401-50ul
Manufacturer	NKMAX
Amount	50 ul
Quantity options	100 ul 50 ul
Category	Antibodies Primary Antibodies
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, FC, ELISA
Clone	c9F2
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1 Kappa
Conjugate/Tag	Unconjugated
Citations	Fujii N., et al., (2003) Mol. Vis. 9: 915-22. Laksanalamai P., et al., (2004) Extremophiles 8: 1-11. Oh JY, et al. Identification of the HSPB4/TLR2/NF-κB axis in macrophage as a therapeutic target for sterile inflammation of the cornea. (EMBO Mol Med. 2012){https://pubmed.ncbi.nlm.nih.gov/22359280/} Fan Q, et al. Identification of proteins that interact with alpha A-crystallin using a human proteome microarray. (Mol Vis. 2014){https://pubmed.ncbi.nlm.nih.gov/24453475/}
NCBI	NP_000385
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Acry-1,Alpha crystallin A chain,CRYA1,CRYAA,Crystallin alpha 1,Crystallin alpha A,Heat shock protein beta 4,HSPB 4,HspB4,Zonular Central Nuclear Cataract
Similar products	CRYAA, CRYA1, Alpha-crystallin A chain, Heat shock protein beta-4, Alpha crystallin A chain, CRYA 1, Crystallin alpha A, Heat shock protein beta 4, HSPB 4, HspB4, Zonular Central Nuclear Cataract, a A Crystallin, Acry-1, Crystallin Alpha 1, ACA0401-10ug, ACA0401-20ug, ACA0401-50ug, ACA0401-100ug, ACA0401-250ug, ACA0401-500ug, ACA0401-1mg, ACA0401-010, ACA0401-020, ACA0401-050, ACA0401-100, ACA0401-250, ACA0401-500, ACA0401-01M
Available
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Applications	ELISA, WB, FACS
Storage Conditions	Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Description	alpha-crystallins, a major protein of the ocular lens, are thought to play a role in maintaining lens transparency, which are composed of two gene products alpha-A and alpha-B, for acidic and basic, respectively. alpha-crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP). They act as molecular chaperones and hold unfolded or misfolded proteins in large, water-soluble low molecular weight aggregates. These heterogeneous aggregates consist of 30-40 subunits of the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional function of alpha-crystallins are an autokinase activity and the participation in the intracellular architecture.
Concentration	1mg/ml (determined by BCA assay)
Formulation	Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Immunogen	Recombinant human Crystallin alpha A (1-173aa) purified from E. coli
Ab Usage	The antibody has been tested by ELISA, Western blot and FACS analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Antigen Species	Human
Clonality	Monoclonal
Ab Purification Comment	By protein-G affinity chromatography
Gene Category	Heat Shock Proteins
Manufacturer - Search Terms	a A Crystallin, Acry-1, Alpha crystallin A chain, Alpha-crystallin A chain, CRYA 1, CRYA1, CRYAA, Crystallin Alpha 1, Crystallin alpha A, Heat shock protein beta 4, Heat shock protein beta-4, HSPB 4, HspB4, Zonular Central Nuclear Cataract, ACA0401-10ug, ACA0401-20ug, ACA0401-50ug, ACA0401-100ug, ACA0401-250ug, ACA0401-500ug, ACA0401-1mg, ACA0401-010, ACA0401-020, ACA0401-050, ACA0401-100, ACA0401-250, ACA0401-500, ACA0401-01M

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ul

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Delivery expected until 9/4/2025

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