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Human SETD7 antibody

Human SETD7 antibody

Item no.	NKM-AHR0401-50ul
Manufacturer	NKMAX
Amount	50 ul
Quantity options	100 ul 50 ul
Category	Antibodies Primary Antibodies
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, FC, ICC, ELISA
Clone	s4E5
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2b Kappa
Conjugate/Tag	Unconjugated
Citations	Bing X, et al., (2003) Nature 421: 652-56. Taewoo K, et al., (2003) EMBO. 22: 292-303. Nishioka K, et al., (2002) Genes Dev. 16: 479-89. Kurash JK, et al. Methylation of p53 by Set7/9 mediates p53 acetylation and activity in vivo. (Mol Cell. 2008){https://pubmed.ncbi.nlm.nih.gov/18280244/} Tao Y, et al. The histone methyltransferase Set7/9 promotes myoblast differentiation and myofibril assembly. (J Cell Biol. 2011){https://pubmed.ncbi.nlm.nih.gov/21859860/} Han T, et al. Set7 facilitates hepatitis C virus replication via enzymatic activity-dependent attenuation of the IFN-related pathway. (J Immunol. 2015){https://pubmed.ncbi.nlm.nih.gov/25681344/} Zhang Y, et al. The transcription factor GATA1 and the histone methyltransferase SET7 interact to promote VEGF-mediated angiogenesis and tumor growth and predict clinical outcome of breast cancer. (Oncotarget. 2016){https://pubmed.ncbi.nlm.nih.gov/26848522/} Yuan H, et al. Epigenetic Histone Modifications Involved in Profibrotic Gene Regulation by 12/15-Lipoxygenase and Its Oxidized Lipid Products in Diabetic Nephropathy. (Antioxid Redox Signal. 2016){https://pubmed.ncbi.nlm.nih.gov/26492974/} Xu X, et al. A signature motif in LIM proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity. (Nat Commun. 2017){https://pubmed.ncbi.nlm.nih.gov/28094252/}
NCBI	NP_085151
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	SETD7, SET7, SET9, SET7/9, SET7/9 Histone methyltransferase, SET domain-containing protein 8, SET domain-containing protein 7 FLJ21193, SET domain-containing protein 7, Lysine N-methyltransferase 7, Lysine methyltransferase, KMT7, KIAA1717, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase, Histone lysine N methyltransferase H3 lysine 4 specific SET7, Histone lysine methyltransferase, Histone H4-K4 methyltransferase, Histone H3-K4 methyltransferase SETD7, Histone H3 lysine 4 specific methyltransferase, Histone H3 K4 methyltransferase, H4 lysine-4 specific, H3-K4-HMTase SETD7, H3 K4 HMTase, EC 2.1.1.43
Similar products	SETD7, SET domain-containing protein 8, KIAA1717, KMT7, SET7, SET9, Histone-lysine N-methyltransferase SETD7, Histone H3-K4 methyltransferase SETD7, Lysine N-methyltransferase 7, SET domain-containing protein 7, SET7/9, H3-K4-HMTase SETD7, EC 2.1.1.43, Histone-lysine N-methyltransferase, H3 K4 HMTase, Histone H3 K4 methyltransferase, Lysine methyltransferase, SET 7, SET 7/9, SET 9, SET D7, SET domain containing protein 7, Histone H3 lysine 4 specific methyltransferase, Histone lysine N methyltransferase H3 lysine 4 specific SET7, SET7/9 Histone methyltransferase, SET domain-containing protein 7 FLJ21193, Histone lysine methyltransferase, Histone H4-K4 methyltransferase, H4 lysine-4 specific, AHR0401-10ug, AHR0401-20ug, AHR0401-50ug, AHR0401-100ug, AHR0401-250ug, AHR0401-500ug, AHR0401-1mg, AHR0401-010, AHR0401-020, AHR0401-050, AHR0401-100, AHR0401-250, AHR0401-500, AHR0401-01M
Available
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Applications	ELISA, WB, ICC/IF, FACS
Storage Conditions	Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Description	SET 7/9 is a histone methyltransferase (HMTase) that transfers methyl group to Lys4 of histone H3, in complex with S-adenosyl-L-methionine (AdoMet). The methylation of lysine residues of histones plays a critical role in the regulation of chromatin structure and gene expression. Acetylation, phosphorylation and methylation of the amino-terminal tails of histone are thought to be involved in the regulation of chromatin structure and function. The enzymes identified in the methylation of specific lysine residue on histones belong to the SET family with just one exception. Set7/9, unlike most other SET proteins, is exclusively a mono-methylase.
Concentration	1mg/ml (determined by BCA assay)
Formulation	Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Immunogen	Recombinant human SET 7/9 (1-366aa) purified from E. coli
Ab Usage	The antibody has been tested by ELISA, Western blot, ICC/IF and FACS analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtainoptimal results.
Antigen Species	Human
Clonality	Monoclonal
Ab Purification Comment	By protein-A affinity chromatography
Gene Category	Signal Transduction
Manufacturer - Search Terms	SETD7, SET9, SET7/9 Histone methyltransferase, SET7/9, SET7, SET domain-containing protein 8, SET domain-containing protein 7 FLJ21193, SET domain-containing protein 7, SET domain containing protein 7, SET D7, SET 9, SET 7/9, SET 7, Lysine N-methyltransferase 7, Lysine methyltransferase, KMT7, KIAA1717, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase, Histone lysine N methyltransferase H3 lysine 4 specific SET7, Histone lysine methyltransferase, Histone H4-K4 methyltransferase, Histone H3-K4 methyltransferase SETD7, Histone H3 lysine 4 specific methyltransferase, Histone H3 K4 methyltransferase, H4 lysine-4 specific, H3-K4-HMTase SETD7, H3 K4 HMTase, EC 2.1.1.43, AHR0401-10ug, AHR0401-20ug, AHR0401-50ug, AHR0401-100ug, AHR0401-250ug, AHR0401-500ug, AHR0401-1mg, AHR0401-010, AHR0401-020, AHR0401-050, AHR0401-100, AHR0401-250, AHR0401-500, AHR0401-01M
Manufacturer - Alternative Names	SETD7, SET7, SET9, SET7/9, SET7/9 Histone methyltransferase, SET domain-containing protein 8, SET domain-containing protein 7 FLJ21193, SET domain-containing protein 7, Lysine N-methyltransferase 7, Lysine methyltransferase, KMT7, KIAA1717, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase, Histone lysine N methyltransferase H3 lysine 4 specific SET7, Histone lysine methyltransferase, Histone H4-K4 methyltransferase, Histone H3-K4 methyltransferase SETD7, Histone H3 lysine 4 specific methyltransferase, Histone H3 K4 methyltransferase, H4 lysine-4 specific, H3-K4-HMTase SETD7, H3 K4 HMTase, EC 2.1.1.43

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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