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Human RASSF1A antibody

Human RASSF1A antibody

Item no.	NKM-ARF0501-100ul
Manufacturer	NKMAX
Amount	100 ul
Quantity options	100 ul 50 ul
Category	Antibodies Primary Antibodies
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, ICC, ELISA
Clone	3F3
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1 Kappa
Conjugate/Tag	Unconjugated
Citations	Agathanggelou A, et al., (2005) Cancer Res. 65, 3497-3508. Lerman MI. et. al. (2000) Cancer Res. 60, 6116-6133. Strunnikova M. et al., (2005) Mol Cell Biol. 25, 3923-3933. Dammann R. et al., (2005) Histol Histopathol. 20, 645-663. Rossa W.k, et al., (2007) American Journal of pathology. 170, 941-950. Thaler S, et al. RASSF1A inhibits estrogen receptor alpha expression and estrogen-independent signalling: implications for breast cancer development. (Oncogene. 2012){https://pubmed.ncbi.nlm.nih.gov/22266866/} Dratviman-Storobinsky O, et al. The role of RASSF1A in uveal melanoma. (Invest Ophthalmol Vis Sci. 2012){https://pubmed.ncbi.nlm.nih.gov/22447862/} Gou HF, et al. Epidermal growth factor receptor (EGFR)-RAS signaling pathway in penile squamous cell carcinoma. (PLoS One. 2013){https://pubmed.ncbi.nlm.nih.gov/23637996/} Korah R, et al. Epigenetic silencing of RASSF1A deregulates cytoskeleton and promotes malignant behavior of adrenocortical carcinoma. (Mol Cancer. 2013){https://pubmed.ncbi.nlm.nih.gov/23915220/} Beckedorff FC, et al. The intronic long noncoding RNA ANRASSF1 recruits PRC2 to the RASSF1A promoter, reducing the expression of RASSF1A and increasing cell proliferation. (PLoS Genet. 2013){https://pubmed.ncbi.nlm.nih.gov/23990798/} Ram RR, et al. RASSF1A inactivation unleashes a tumor suppressor/oncogene cascade with context-dependent consequences on cell cycle progression. (Mol Cell Biol. 2014){https://pubmed.ncbi.nlm.nih.gov/24732797/} Pruikkonen S, Kallio MJ. Excess of a Rassf1-targeting microRNA, miR-193a-3p, perturbs cell division fidelity. (Br J Cancer. 2017){https://pubmed.ncbi.nlm.nih.gov/28449010/} Li W, et al. Suppressor of hepatocellular carcinoma RASSF1A activates autophagy initiation and maturation. (Cell Death Differ. 2019){https://pubmed.ncbi.nlm.nih.gov/30315205/} Guo M, et al. RASSF1-AS1, an antisense lncRNA of RASSF1A, inhibits the translation of RASSF1A to exacerbate cardiac fibrosis in mice. (Cell Biol Int. 2019){https://pubmed.ncbi.nlm.nih.gov/30571844/} Dabral S, et al. A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension. (Nat Commun. 2019){https://pubmed.ncbi.nlm.nih.gov/31086178/} Francisco J, et al. The tumor suppressor RASSF1A modulates inflammation and injury in the reperfused murine myocardium. (J Biol Chem. 2019){https://pubmed.ncbi.nlm.nih.gov/31311858/} Chen J, et al. 5-Aza-CdR Regulates RASSF1A By Inhibiting DNMT1 To Affect Colon Cancer Cell Proliferation, Migration And Apoptosis. (Cancer Manag Res. 2019){https://pubmed.ncbi.nlm.nih.gov/31807076/} Slemmons KK, et al. Targeting Hippo-Dependent and Hippo-Independent YAP1 Signaling for the Treatment of Childhood Rhabdomyosarcoma. (Cancer Res. 2020){https://pubmed.ncbi.nlm.nih.gov/32354737/} Dhanaraman T, et al. RASSF effectors couple diverse RAS subfamily GTPases to the Hippo pathway. (Sci Signal. 2020){https://pubmed.ncbi.nlm.nih.gov/33051258/} Jeon HJ, Oh JS. RASSF1A Regulates Spindle Organization by Modulating Tubulin Acetylation via SIRT2 and HDAC6 in Mouse Oocytes. (Front Cell Dev Biol. 2020){https://pubmed.ncbi.nlm.nih.gov/33195286/} Jia J, et al. RAS-association domain family 1A regulates the abnormal cell proliferation in psoriasis via inhibition of Yes-associated protein. (J Cell Mol Med. 2021){https://pubmed.ncbi.nlm.nih.gov/33960627/} Roßwag S, et al. RASSF1A-Mediated Suppression of Estrogen Receptor Alpha (ERα)-Driven Breast Cancer Cell Growth Depends on the Hippo-Kinases LATS1 and 2. (Cells. 2021){https://pubmed.ncbi.nlm.nih.gov/34831091/}
NCBI	NP_009113
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	RASSF1(Ras association (RalGDS/AF-6) domain family 1),123F2,RDA32,NORE2A,RASSF1A,REH3P21,Ras association (RalGDS/AF-6) domain family member 1
Similar products	RASSF1A, ARF0501-10ug, ARF0501-20ug, ARF0501-50ug, ARF0501-100ug, ARF0501-250ug, ARF0501-500ug, ARF0501-1mg, ARF0501-10, ARF0501-20, ARF0501-50, ARF0501-100, ARF0501-250, ARF0501-500, ARF0501-1
Available
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Applications	ELISA, WB, ICC/IF
Storage Conditions	Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Description	The tumor suppressor gene RASSF1A (3p21.3), human Ras association domain family 1A, is expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, small intestine, colon, and peripheral blood leukocytes. RASSF1A expression is inhibited by hypermethylation of the CpG island including the promoter and early transcribed regions of the human RASSF1A gene. Hypermethylated RASSF1A promoter is observed in primary tumors. Furthermore, RASSF1A is related with cell cycle regulation, apoptosis and microtubule stability.
Concentration	1mg/ml (determined by BCA assay)
Formulation	Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Immunogen	Recombinant human RASSF1A (1-340aa) purified from E. coli.
Ab Usage	The antibody has been tested by ELISA, Western blot and ICC/IF analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Antigen Species	Human
Clonality	Monoclonal
Ab Purification Comment	By protein-A affinity chromatography
Gene Category	Cancer
Manufacturer - Search Terms	RASSF1A, ARF0501-10ug, ARF0501-20ug, ARF0501-50ug, ARF0501-100ug, ARF0501-250ug, ARF0501-500ug, ARF0501-1mg, ARF0501-10, ARF0501-20, ARF0501-50, ARF0501-100, ARF0501-250, ARF0501-500, ARF0501-1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ul

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