Comparison

Human SMAC/Diablo antibody

Item no. NKM-ATGA0266-50ul
Manufacturer NKMAX
Amount 50 ul
Quantity options 100 ul 50 ul
Category
Type Antibody Monoclonal
Format Liquid
Applications WB, FC, ICC, ELISA
Clone AT19F2
Specific against Human (Homo sapiens)
Host Mouse
Isotype IgG2a Kappa
Conjugate/Tag Unconjugated
Citations McNeish. I.A., et al. (2003) Exp Cell Res 286(2): 186-198.
Yu. J., et al. (2007) Oncogene 26(29): 4189-4198.
Vucic. D., et al. (2002) J Biol Chem 277(14): 12275-12279.
NCBI NP_063940
ECLASS 10.1 42030590
ECLASS 11.0 42030590
UNSPSC 12352203
Alias Diablo isoform 1, SMAC3, DIABLO-S, FLJ10537, FLJ25049, Diablo isoform 1, SMAC/Diablo, Diablo isoform 1 0610041G12Rik, DBOH, Diablo homolog, DIABLO S, Diablo homolog (Drosophila), Mitochondrial Smac protein, Diablo homolog mitochondrial, SMAC 3, Smac protein, Direct IAP binding protein with low pI, Second mitochondria derived activator of caspase
Similar products SMADiablo, ATGA0266-10ug, ATGA0266-20ug, ATGA0266-50ug, ATGA0266-100ug, ATGA0266-250ug, ATGA0266-500ug, ATGA0266-1mg, ATGA0266-10, ATGA0266-20, ATGA0266-50, ATGA0266-100, ATGA0266-250, ATGA0266-500, ATGA0266-1
Available
Manufacturer - Type
Monoclonal Antibody
Manufacturer - Applications
ELISA, WB, ICC/IF, FACS
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Description
SMAC/Diablo is one of the proapoptotic proteins. SMAC promotes caspase activation in the cytochrome c/Apaf-1/caspase-9 pathway by binding to inhibitor of apoptosis proteins (IAPs) and removing their inhibitory activity. In healthy cells, SMAC is a mitochondrial protein, but when cells undergo apoptosis, SMAC is released into the cytosol. SMAC is ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes
Concentration
1mg/ml (determined by BCA assay)
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Immunogen
Recombinant human SMAC/Diablo (56-239aa) purified from E. coli
Ab Usage
The antibody has been tested by ELISA, Western blot, ICC/IF and FACS analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Antigen Species
Human
Clonality
Monoclonal
Ab Purification Comment
By protein-A affinity chromatography
Gene Category
Cancer
Manufacturer - Search Terms
SMADiablo, ATGA0266-10ug, ATGA0266-20ug, ATGA0266-50ug, ATGA0266-100ug, ATGA0266-250ug, ATGA0266-500ug, ATGA0266-1mg, ATGA0266-10, ATGA0266-20, ATGA0266-50, ATGA0266-100, ATGA0266-250, ATGA0266-500, ATGA0266-1
Manufacturer - Alternative Names
Diablo isoform 1, SMAC3, DIABLO-S, FLJ10537, FLJ25049, Diablo isoform 1, SMAC/Diablo, Diablo isoform 1 0610041G12Rik, DBOH, Diablo homolog, DIABLO S, Diablo homolog (Drosophila), Mitochondrial Smac protein, Diablo homolog mitochondrial, SMAC 3, Smac protein, Direct IAP binding protein with low pI, Second mitochondria derived activator of caspase

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 50 ul
Available: In stock
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