Comparison

Human PKM antibody

Item no. NKM-ATGA0325-50ul
Manufacturer NKMAX
Amount 50 ul
Quantity options 100 ul 50 ul
Category
Type Antibody Monoclonal
Format Liquid
Applications WB, ICC, ELISA
Clone AT1B10
Specific against Human (Homo sapiens)
Host Mouse
Isotype IgG1 Kappa
Conjugate/Tag Unconjugated
Citations Ferguson E.C., et al. (2008) Trends Biochem Sci 33(8): 359-362.
Christofk H.R., et al. (2008) Nature 452(7184):181-186.
Shimada N., et al. (2008) Genes Cells 13(3): 245-254.
NCBI NP_002645
ECLASS 10.1 42030590
ECLASS 11.0 42030590
UNSPSC 12352203
Alias Pyruvate kinase muscle isoform M2, Pyruvate kinase M1/2, Pyruvate kinase muscle, Cytosolic thyroid hormone-binding protein, CTHBP, Pyruvate kinase 2/3, Threonine-protein kinase PKM2, Thyroid hormone-binding protein 1, THBP1, Opa-interacting protein 3, OIP3, Tumor M2-PK, Tyrosine-protein kinase PKM2, PK2, PK3, PKM2, p58
Similar products PKM2, PKM, PK2, PK3, Pyruvate kinase isozymes M1/M2, Pyruvate kinase 2/3, Tumor M2-PK, p58, M2-PK, pyruvate kinase, CTHBP, TCB, THBP1, Tumor Type M2 Pyruvate Kinase, Cytosolic thyroid hormone binding protein, OPA interacting protein 3, Pyruvate kinase muscle, Thyroid hormone binding protein cytosolic, pyruvate kinase muscle isoform M2, muscle isoform M2 OIP3, Tumour Type M2 Pyruvate Kinase, ATGA0325-10ug, ATGA0325-20ug, ATGA0325-50ug, ATGA0325-100ug, ATGA0325-250ug, ATGA0325-500ug, ATGA0325-1mg, ATGA0325-10, ATGA0325-20, ATGA0325-50, ATGA0325-100, ATGA0325-250, ATGA0325-500, ATGA0325-1
Available
Manufacturer - Type
Monoclonal Antibody
Manufacturer - Applications
ELISA, WB, ICC/IF
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Description
PKM2 (pyruvate kinase M2), its association with phospho-tyrosine (pTyr) motifs, enables cells to use predominantly aerobic glycolysis instead of oxidative phosphorylation. Also PKM2 suggest that this change benefits cancer cells by enabling them to redirect glycolytic metabolites away from oxidation and energy production and, instead, toward anabolic processes and biosynthesis. PKM2-mediated generation of the aerobic glycolytic phenotype, although wasteful in terms of glucose consumption and waste generation, could provide a variety of advantages for cancerous cells. In addition nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death.
Concentration
1mg/ml (determined by BCA assay)
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Immunogen
Recombinant human PKM2 (1-531aa) purified from E.coli
Ab Usage
The antibody has been tested by ELISA, Western blot analysis and Immunofluorescence analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution for Western blot analysis is 1:1000 and Immunofluorescence is 1:250.
Antigen Species
Human
Clonality
Monoclonal
Ab Purification Comment
By protein-A affinity chromatography
Gene Category
Signal Transduction
Manufacturer - Search Terms
PKM2, pyruvate kinase muscle isoform M2, CTHBP, THBP1, p58, M2-PK, Tumor M2-PK, PK2, PK3, PKM, pyruvate kinase, muscle isoform M2 OIP3, PKM, TCB, OPA interacting protein 3, PKM2, Cytosolic thyroid hormone binding protein, Pyruvate kinase 2/3, Pyruvate kinase isozymes M1/M2, Pyruvate kinase muscle, Thyroid hormone binding protein cytosolic, Tumour Type M2 Pyruvate Kinase, Tumor Type M2 Pyruvate Kinase, ATGA0325-10ug, ATGA0325-20ug, ATGA0325-50ug, ATGA0325-100ug, ATGA0325-250ug, ATGA0325-500ug, ATGA0325-1mg, ATGA0325-10, ATGA0325-20, ATGA0325-50, ATGA0325-100, ATGA0325-250, ATGA0325-500, ATGA0325-1
Manufacturer - Alternative Names
Pyruvate kinase muscle isoform M2, Pyruvate kinase M1/2, Pyruvate kinase muscle, Cytosolic thyroid hormone-binding protein, CTHBP, Pyruvate kinase 2/3, Threonine-protein kinase PKM2, Thyroid hormone-binding protein 1, THBP1, Opa-interacting protein 3, OIP3, Tumor M2-PK, Tyrosine-protein kinase PKM2, PK2, PK3, PKM2, p58

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 50 ul
Available: In stock
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