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Human Thioredoxin Reductase 1/TRXR1 antibody

Human Thioredoxin Reductase 1/TRXR1 antibody

Item no.	NKM-ATGA0451-100ul
Manufacturer	NKMAX
Amount	100 ul
Quantity options	100 ul 50 ul
Category	Oncology Antibodies By Cell Type Carcinoma Cell Biology Cell Status Western Blot ELISA Immunocytochemistry Senescence Primary Antibodies Immunostaining Immunochemistry
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, ICC, ELISA
Clone	AT30F1
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2b Kappa
Conjugate/Tag	Unconjugated
Citations	Ma X., et al. (2002) J Biol Chem. 277(25): 22460-8. Javvadi P (2010) Cancer Res. 70(5): 1941-50.
NCBI	NP_001087240
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Available
Manufacturer - Type	Antibodies
Manufacturer - Applications	ELISA, WB, ICC/IF
Manufacturer - Category	Monoclonal Antibody
Storage Conditions	Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Description	TXNRD1, also known as Thioredoxin reductase 1, is a part of a selenium-containing pyridine nucleotidedisulphide oxidoreductase family, which has a conserved catalytic site of Cys-Val-Asn-Val-Gly-Cys. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. Inhibition of TXNRD1 activity may provide for potential treatments of cancer, AIDS and other autoimmune diseases as well as bacterial infections and parasitic diseases.
Concentration	1mg/ml (determined by BCA assay)
Formulation	Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Immunogen	Recombinant human TXNRD1 (161-647aa) purified from E. coli
Ab Usage	The antibody has been tested by ELISA, Western blot analysis, Flow cytometry and ICC/IF to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Antigen Species	Human
Clonality	Monoclonal
Ab Purification Comment	By protein-A affinity chromatography
Gene Category	Signal Transduction
Manufacturer - Search Terms	GRIM 12, GRIM12, GRIM-12, KDRF, KM 102 derived reductase like factor, MGC9145, Oxidoreductase, Thioredoxin reductase, Thioredoxin reductase 1, Thioredoxin reductase 1 cytoplasmic, Thioredoxin reductase 1 Gene associated with retinoid IFN induced mortality 12 protein, Thioredoxin reductase GRIM 12, Thioredoxin reductase GRIM12, TR, TR 1, TR1, TR-1, TRXR 1, TRXR1, TRXR-1, TXNR, TXNRD 1, TXNRD1, TXNRD-1, ATGA0451-10ug, ATGA0451-20ug, ATGA0451-50ug, ATGA0451-100ug, ATGA0451-250ug, ATGA0451-500ug, ATGA0451-1mg, ATGA0451-010, ATGA0451-020, ATGA0451-050, ATGA0451-100, ATGA0451-250, ATGA0451-500, ATGA0451-01M
Manufacturer - Alternative Names	GRIM 12, KDRF, KM 102 derived reductase like factor, MGC9145, Oxidoreductase, Thioredoxin reductase, Thioredoxin reductase 1, Thioredoxin reductase 1 cytoplasmic, Thioredoxin reductase 1 Gene associated with retinoid IFN induced mortality 12 protein, Thioredoxin reductase GRIM 12, TR, TR 1, TRXR 1, TXNR, TXNRD 1
Manufacturer - Similar Names	GRIM 12, GRIM12, GRIM-12, KDRF, KM 102 derived reductase like factor, MGC9145, Oxidoreductase, Thioredoxin reductase, Thioredoxin reductase 1, Thioredoxin reductase 1 cytoplasmic, Thioredoxin reductase 1 Gene associated with retinoid IFN induced mortality 12 protein, Thioredoxin reductase GRIM 12, Thioredoxin reductase GRIM12, TR, TR 1, TR1, TR-1, TRXR 1, TRXR1, TRXR-1, TXNR, TXNRD 1, TXNRD1, TXNRD-1, ATGA0451-10ug, ATGA0451-20ug, ATGA0451-50ug, ATGA0451-100ug, ATGA0451-250ug, ATGA0451-500ug, ATGA0451-1mg, ATGA0451-010, ATGA0451-020, ATGA0451-050, ATGA0451-100, ATGA0451-250, ATGA0451-500, ATGA0451-01M
IF Comment	ICC/IF analysis of TXNRD1 in Hep3B cells line, stained with DAPI (Blue) for nucleus staining and monoclonal anti-human TXNRD1 antibody (1:100) with goat anti-mouse IgG-Alexa fluor 488 conjugate (Green). {ATGA0451-IF1b.jpg}ICC/IF analysis of TXNRD1 in A549 cells line, stained with DAPI (Blue) for nucleus staining and monoclonal anti-human TXNRD1 antibody (1:100) with goat anti-mouse IgG-Alexa fluor 488 conjugate (Green). {ATGA0451-IF2a.jpg} {ATGA0451-IF2b.jpg}
WB Comment	The cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human TXNRD1 antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Lane 1.: HeLa cell lysate Lane 2.: A549 cell lysate Lane 3.: PC3 cell lysate

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ul

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Delivery expected until 12/4/2025

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