Bax Antibody (Phospho-Ser184)

Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin

Wet Ice

IHC: 1:50~1:100
ELISA: 1:10000

BCL2 associated X, apoptosis regulator

Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) (PubMed:21458670). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.

Polyclonal

The antiserum was produced against synthesized peptide derived from human Bax around the phosphorylation site of Ser184.

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.