Comparison

DNMT1 Antibody (OAAN03507)

Item no. OAAN03507
Manufacturer AVIVA Systems Biology
Amount 50UL
Category
Type Antibody Polyclonal
Applications WB, IF, IP, IHC, CHIP
Specific against other
Host Rabbit
Isotype IgG
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Available
Gene symbol
DNMT1
Protein name
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
Molecular weight
183 kDa
Product format
Liquid
Gene id
1786
Reconstitution and storage
Store at +4C. For long term storage, aliquote and store at -20C. Avoid freeze/thaw cycles.
Description of target
Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells.
Purification
Affinity purification
Clonality
Polyclonal
Formulation
PBS with 0.02% sodium azide, 50% glyceron, pH 7.3
Immunogen
Recombinant Protein
Drywet
Wet Ice

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 50UL
Available: In stock
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