FE65 Antibody

Polyclonal Antibody

PLEKHA1

Liquid

APBB1 is also known as RIR or FE65. The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Recombinant Monoclonal

A synthesized peptide derived from human PLEKHA1

Binds specifically to phosphatidylinositol 3, 4-diphosphate (PtdIns3, 4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane.