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LRP5 Antibody (OABF01398-100UL)

LRP5 Antibody (OABF01398-100UL)

Item no.	OABF01398
Manufacturer	AVIVA Systems Biology
Amount	100 ul
Category	Oncology Neuroscience Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Neural Mitochondrial Function Molecular Targets for Neuroscience Aging & Neurological Disorders Antibodies By Cell Type Carcinoma Cell Biology Obesity Cell Status Apoptosis Immunohistochemistry Western Blot ELISA Immunofluorescence Immunocytochemistry Lipoprotein Receptors & Associated Proteins Primary Antibodies Immunostaining Immunochemistry
Type	Antibody Polyclonal
Format	Liquid
Applications	IF, IHC, ICC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus), Rabbit (Oryctolagus cuniculus), Chicken (Gallus gallus domesticus), Dog (Canine, Canis lupus familiaris), Horse (Equine), Cattle (Bovine)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	BMND1;EVR1;EVR4;HBM;low density lipoprotein receptor-related protein 5;low density lipoprotein receptor-related protein 7;low-density lipoprotein receptor-related protein 5;LR3;LRP-5;LRP7;LRP-7;OPPG;OPS;OPTA1;PCLD4;VBCH2.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Applications	Enzyme-linked immunosorbent assay\|Immunocytochemistry\|Immunofluorescence\|Immunohistochemistry-Frozen\|Immunohistochemistry-Paraffin
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Manufacturer - Application Additional Information	WB: 1:100~1000 IHC-P: 1:100~500 Fluorescent-IHC: 1:50~200
Gene symbol	LRP5
Gene Fullname	LDL receptor related protein 5
Product format	Liquid Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
Reconstitution and storage	-20°C
Description of target	Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. Plays a role in norrin (NDP) signal transduction (PubMed:27228167). The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye (By similarity). Required for posterior patterning of the epiblast during gastrulation (By similarity).
Protein name	Low-density lipoprotein receptor-related protein 5
Clonality	Polyclonal
Purification	Protein A Purified
Immunogen	KLH conjugated synthetic peptide derived from human LRP5
Concentration	1 ug/ul

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ul

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Delivery expected until 12/25/2025

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