VEGFR2 Antibody (OABI00013)

151 kDa

3791

In recent decades, a variety of signaling molecules, such as VEGF-VEGFRs, ephrin-Eph receptors, angiopoietin-Tie, and the Delta-Notch system, have been identified as playing important roles in angiogenesis. Among these, vascular endothelial growth factors (VEGFs) and receptors (VEGFRs) regulate both vasculogenesis, the development of blood vessels from precursor cells during early embryogenesis, and angiogenesis, the formation of blood vessels from pre-existing vessels at a later stage3. VEGFR-1 and VEGFR-2 play major roles in physiological as well as pathological angiogenesis, including tumor angiogenesis.VEGFR-2, the major signal transducer for angiogenesis, preferentially utilizes the PLC gamma-PKC-MAPK pathway for signaling.

Polyclonal

KLH conjugated synthetic peptide derived from human VEGFR2.