APEX1 Antibody (OACA02420)

DNA-(apurinic or apyrimidinic site) lyase

36 kDa

328

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.

Caprylic Acid Ammonium Sulfate Precipitation purified

Provided in PBS, pH 7.4, 50% Glycerol, 0.03% Proclin 300

Wet Ice