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GRK4 Antibody

GRK4 Antibody

Item no.	OACA03068
Manufacturer	AVIVA Systems Biology
Amount	50 ug
Category	Neuroscience Metabolism Diabetes Glucose Homeostasis Neural Signaling Antibodies Obesity Immunohistochemistry Western Blot ELISA Immunofluorescence Cardiovascular Research Heart Failure Myocardial Infarction Hypertension Primary Antibodies Arrhythmias Immunostaining
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, IF, IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	[1]"Patterns of somatic mutation in human cancer genomes."Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. Stratton M.R.Nature 446:153-158(2007). [2]"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features." Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012). [3]"G protein-coupled receptor kinase 4 (GRK4) regulates the phosphorylation and function of the dopamine D3 receptor."Villar V.A.M., Jones J.E., Armando I., Palmes-Saloma C., Yu P., Pascua A.M., Keever L., Arnaldo F.B., Wang Z., Luo Y., Felder R.A., Jose P.A.J. Biol. Chem. 284:21425-21434(2009).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	G protein-coupled receptor kinase 2-like;G protein-coupled receptor kinase 4;G protein-coupled receptor kinase GRK4;GPRK2L;GPRK4;GRK4a;IT11;ITI1.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	GRK4
Gene Fullname	G protein-coupled receptor kinase 4
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2.
Nucleotide accession_num	NM_001004056
Protein accession_num	NP_001004056
Protein name	G protein-coupled receptor kinase 4
Clonality	Polyclonal
Purification	Protein G Purified
Immunogen	Recombinant Human G protein-coupled receptor kinase 4 protein (1-245AA)
Formulation	50% Glycerol, 0.01M PBS, PH 7.4

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ug

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Delivery expected until 12/25/2025

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