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GCKR Antibody

GCKR Antibody

Item no.	OACA04783
Manufacturer	AVIVA Systems Biology
Amount	50 ug
Category	Metabolism Diabetes Glucose Homeostasis Antibodies Immunohistochemistry Western Blot ELISA Primary Antibodies Immunostaining
Type	Antibody Polyclonal
Format	Liquid
Applications	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	[1]Molecular basis for the role of glucokinase regulatory protein as the allosteric switch for glucokinase. Choi J.M., Seo M.H., Kyeong H.H., Kim E., Kim H.S. Proc. Natl. Acad. Sci. U.S.A. 110:10171-10176(2013). [2]The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver. Beer N.L., Tribble N.D., McCulloch L.J., Roos C., Johnson P.R., Orho-Melander M., Gloyn A.L. Hum. Mol. Genet. 18:4081-4088(2009). [3]Crystal structure of glucokinase regulatory protein. Pautsch A., Stadler N., Lohle A., Rist W., Berg A., Glocker L., Nar H., Reinert D., Lenter M., Heckel A., Schnapp G., Kauschke S.G. Biochemistry 52:3523-3531(2013)
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	FGQTL5;GKRP;glucokinase (hexokinase 4) regulator;glucokinase regulatory protein;hexokinase 4 regulator.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	GCKR
Gene Fullname	glucokinase regulator
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity.
Nucleotide accession_num	NM_001486
Protein accession_num	NP_001477
Protein name	Glucokinase regulatory protein
Clonality	Polyclonal
Purification	Protein G Purified
Immunogen	Recombinant Human Glucokinase regulatory protein (1-625AA)
Formulation	50% Glycerol, 0.01M PBS, PH 7.4

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ug

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Delivery expected until 12/25/2025

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