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MMP14 Antibody

MMP14 Antibody

Item no.	OACA06939
Manufacturer	AVIVA Systems Biology
Amount	50 ul
Category	Oncology Neuroscience Neuroinflammation Aging & Neurological Disorders Antibodies By Cell Type Blastoma Carcinoma Immunohistochemistry Western Blot ELISA Primary Antibodies Immunostaining
Type	Antibody Polyclonal
Format	Liquid
Applications	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	[1]"Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas."Okada A., Bellocq J.-P., Rouyer N., Chenard M.P., Rio M.C., Chambon P., Basset P. Proc. Natl. Acad. Sci. U.S.A. 92:2730-2734(1995). [2]"Regulation of membrane-type matrix metalloproteinase-1 expression by growth factors and phorbol 12-myristate 13-acetate."Lohi J.L., Westermarck J., Kaehaeri V.M., Keski-Oja J.Eur. J. Biochem. 239:239-247(1996). [3]"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S. Nat. Genet. 36:40-45(2004).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	matrix metallopeptidase 14 (membrane-inserted);matrix metalloproteinase-14;membrane type 1 metalloprotease;Membrane-type matrix metalloproteinase 1;membrane-type-1 matrix metalloproteinase;MMP-14;MMP-X1;MT1MMP;MT1-MMP;MT-MMP;MT-MMP 1;MTMMP1;WNCHRS.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	MMP14
Gene Fullname	matrix metallopeptidase 14
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity). May be involved in actin cytoskeleton reorganization by cleaving PTK7 (PubMed:20837484). Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2 (PubMed:12714657). Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (PubMed:22330140).
Nucleotide accession_num	NM_004995
Protein accession_num	NP_004986
Protein name	Matrix metalloproteinase-14
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Matrix metalloproteinase-14 protein (260-540AA)
Formulation	PBS with, 50% glycerol, pH7.3.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ul

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