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PAX6 Antibody

PAX6 Antibody

Item no.	OACA07072
Manufacturer	AVIVA Systems Biology
Amount	50 ul
Category	Neuroscience Neural Lineage Markers Neural Transcription Factors Molecular Targets for Neuroscience Neural Development Antibodies Cell Biology Cytoskeleton Immunohistochemistry Western Blot ELISA Primary Antibodies Immunostaining small GTPases Rho Subfamily
Type	Antibody Polyclonal
Format	Liquid
Applications	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	[1]"Mutation spectrum of PAX6 in Chinese patients with aniridia." Zhang X., Wang P., Li S., Xiao X., Guo X., Zhang Q.Mol. Vis. 17:2139-2147(2011). [2]"A de novo nonsense mutation of PAX6 gene in a patient with aniridia, ataxia, and mental retardation."Graziano C., D'Elia A.V., Mazzanti L., Moscano F., Guidelli Guidi S., Scarano E., Turchetti D., Franzoni E., Romeo G., Damante G., Seri M. Am. J. Med. Genet. A 143:1802-1805(2007). [3]"Molecular analysis of a human PAX6 homeobox mutant."D'Elia A.V., Puppin C., Pellizzari L., Pianta A., Bregant E., Lonigro R., Tell G., Fogolari F., van Heyningen V., Damante G.Eur. J. Hum. Genet. 14:744-751(2006).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	AN;AN1;AN2;Aniridia 1;Aniridia 2;aniridia type II protein;ASGD5;D11S812E;FVH1;MGDA;oculorhombin;paired box homeotic gene-6;paired box protein Pax-6;WAGR.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	PAX6
Gene Fullname	paired box 6
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes.
Nucleotide accession_num	NM_000280
Protein accession_num	NP_000271
Protein name	Paired box protein Pax-6
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Paired box protein Pax-6 protein (1-300AA)
Formulation	PBS with, 50% glycerol, pH7.3.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ul

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Delivery expected until 12/11/2025

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