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CD33 Antibody

CD33 Antibody

Item no.	OACA07176
Manufacturer	AVIVA Systems Biology
Amount	50 ul
Category	Oncology Neuroscience Neuroinflammation Antibodies By Cell Type Hematology Leukemia Myeloma Immunohistochemistry Western Blot ELISA Primary Antibodies Immunostaining
Type	Antibody Polyclonal
Format	Liquid
Applications	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	[1]"Surface expression and function of p75/AIRM-1 or CD33 in acute myeloid leukemias: engagement of CD33 induces apoptosis of leukemic cells."Vitale C., Romagnani C., Puccetti A., Olive D., Costello R., Chiossone L., Pitto A., Bacigalupo A., Moretta L., Mingari M.C. Proc. Natl. Acad. Sci. U.S.A. 98:5764-5769(2001). [2]"The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2."Taylor V.C., Buckley C.D., Douglas M., Cody A.J., Simmons D.L., Freeman S.D.J. Biol. Chem. 274:11505-11512(1999). [3]"The sialoadhesin CD33 is a myeloid-specific inhibitory receptor." Ulyanova T., Blasioli J., Woodford-Thomas T.A., Thomas M.L.Eur. J. Immunol. 29:3440-3449(1999).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	CD33 antigen (gp67);CD33 molecule transcript;gp67;myeloid cell surface antigen CD33;p67;sialic acid-binding Ig-like lectin 3;SIGLEC3;SIGLEC-3.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	CD33
Gene Fullname	CD33 molecule
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2, 6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).
Nucleotide accession_num	NM_001082618
Protein accession_num	NP_001076087
Protein name	Myeloid cell surface antigen CD33
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Myeloid cell surface antigen CD33 protein (49-259AA)
Formulation	PBS with, 50% glycerol, pH7.3.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ul

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Delivery expected until 12/25/2025

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