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GRB7 Antibody

GRB7 Antibody

Item no.	OACA07204
Manufacturer	AVIVA Systems Biology
Amount	50 ul
Category	Oncology Neuroscience Neural Lineage Markers Neural Transcription Factors Molecular Targets for Neuroscience Aging & Neurological Disorders Neural Signaling Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Cell Biology Cell Culture Cytokines Adenocarcinoma Cytoskeleton Immunohistochemistry Western Blot ELISA Primary Antibodies Immunostaining small GTPases Ras Subfamily
Type	Antibody Polyclonal
Format	Liquid
Applications	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	[1]"Grb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferation."Porter C.J., Matthews J.M., Mackay J.P., Pursglove S.E., Schmidberger J.W., Leedman P.J., Pero S.C., Krag D.N., Wilce M.C., Wilce J.A. BMC Struct. Biol. 7:58-58(2007). [2]"Solution structure of the RA domain of human GRB7 protein."RIKEN structural genomics initiative (RSGI)Submitted (NOV-2004).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	B47;epidermal growth factor receptor GRB-7;GRB7 adapter protein;growth factor receptor-bound protein 7.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	GRB7
Gene Fullname	growth factor receptor bound protein 7
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity).
Nucleotide accession_num	NM_001030002
Protein accession_num	NP_001025173
Protein name	Growth factor receptor-bound protein 7
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Growth factor receptor-bound protein 7 protein (233-532AA)
Formulation	PBS with, 50% glycerol, pH7.3.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ul

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Delivery expected until 12/11/2025

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