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GCK Antibody

GCK Antibody

Item no.	OACA07292
Manufacturer	AVIVA Systems Biology
Amount	50 ul
Category	Metabolism Diabetes Glucose Homeostasis Antibodies Immunohistochemistry Western Blot ELISA Primary Antibodies Immunostaining
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	[1]"The previously reported T342P GCK missense variant is not a pathogenic mutation causing MODY."Steele A.M., Tribble N.D., Caswell R., Wensley K.J., Hattersley A.T., Gloyn A.L., Ellard S.Diabetologia 54:2202-2205(2010). [2]"Neonatal diabetes mellitus due to complete glucokinase deficiency." Njoelstad P.R., Soevik O., Cuesta-Munoz A., Bjoerkhaug L., Massa O., Barbetti F., Undlien D.E., Shiota C., Magnuson M.A., Molven A., Matschinsky F.M., Bell G.I.N. Engl. J. Med. 344:1588-1592(2000). [4]"Identification of glucokinase mutation in subjects with post-renal transplantation diabetes mellitus."Nam J.H., Lee H.C., Kim Y.H., Cha B.S., Song Y.D., Lim S.K., Kim K.R., Huh K.B.Diabetes Res. Clin. Pract. 50:169-176(1999).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	ATP:D-hexose 6-phosphotransferase;FGQTL3;GK;GLK;glucokinase (hexokinase 4);hexokinase D,pancreatic isozyme;hexokinase type IV;hexokinase-4;Hexokinase-D;HHF3;HK IV;HK4;HKIV;HXKP;LGLK;MODY2;PNDM1.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	GCK
Gene Fullname	glucokinase
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.
Nucleotide accession_num	NM_000162
Protein accession_num	NP_000153
Protein name	Glucokinase
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Glucokinase protein (1-300AA)
Formulation	PBS with, 50% glycerol, pH7.3.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ul

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Delivery expected until 12/25/2025

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