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CD6 Antibody

CD6 Antibody

Item no.	OACA07484
Manufacturer	AVIVA Systems Biology
Amount	50 ul
Category	Metabolism Diabetes Glucose Homeostasis Antibodies Flow Cytometry Immunohistochemistry Immunoprecipitation Western Blot ELISA Primary Antibodies Immunostaining
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	[1]"Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse."Castro M.A., Oliveira M.I., Nunes R.J., Fabre S., Barbosa R., Peixoto A., Brown M.H., Parnes J.R., Bismuth G., Moreira A., Rocha B., Carmo A.M.J. Immunol. 178:4351-4361(2007). [2]"Biosynthesis and post-translational modification of CD6, a T cell signal-transducing molecule."Swack J.A., Mier J.W., Romain P.L., Hull S.R., Rudd C.E. J. Biol. Chem. 266:7137-7143(1991). [3]"Tyrosine phosphorylation of CD6 by stimulation of CD3: augmentation by the CD4 and CD2 coreceptors."Wee S., Schieven G.L., Kirihara J.M., Tsu T.T., Ledbetter J.A., Aruffo A.J. Exp. Med. 177:219-223(1993).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	CD6 antigen;T12;T-cell differentiation antigen CD6;TP120.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	CD6
Gene Fullname	CD6 molecule
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24945728, PubMed:24584089). Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089). Functions as costimulatory molecule; promotes T-cell activation and proliferation (PubMed:15294938, PubMed:16352806, PubMed:16914752). Contributes to the formation and maturation of the immunological synapse (PubMed:15294938, PubMed:16352806). Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria (PubMed:17601777). LPS binding leads to the activation of signaling cascades and down-stream MAP kinases (PubMed:17601777). Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS (PubMed:17601777).
Nucleotide accession_num	NM_001254750
Protein accession_num	NP_001241679
Protein name	T-cell differentiation antigen CD6
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human T-cell differentiation antigen CD6 protein (424-668AA)
Formulation	PBS with, 50% glycerol, pH7.3.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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