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KLRB1 Antibody

KLRB1 Antibody

Item no.	OACD05024
Manufacturer	AVIVA Systems Biology
Amount	100 ul
Category	Oncology Neuroscience Metabolism Cholesterol & Lipid Metabolism Aging & Neurological Disorders Antibodies By Cell Type Blastoma Carcinoma Hematology Lymphoma Myeloma Melanoma Sarcoma Flow Cytometry Immunohistochemistry Immunoprecipitation Western Blot Immunocytochemistry Enzymes Fatty Acid Catabolism Immunoassay Primary Antibodies Immunochemistry
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, IP, IHC, ICC
Specific against	Human (Homo sapiens), Rat (Rattus norvegicus), Pig (Porcine, Sus scrofa domesticus)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	CD161;CLEC5B;C-type lectin domain family 5 member B;hNKR-P1A;killer cell lectin-like receptor subfamily B member 1;killer cell lectin-like receptor subfamily B,member 1;natural killer cell surface protein P1A;NKR;NKR-P1;NKRP1A;NKR-P1A.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Molecular Weight	25 kDa
Application Data	Western blotting: 1:50-400 Immunocytochemistry in formalin fixed cells: 1:50-500 Immunohistochemistry in formalin fixed frozen section: 1:50-500 Immunohistochemistry in paraffin section: 1:10-100 Enzyme-linked Immunosorbent Assay: 1:100-1:5, 000 Optimal working dilutions must be determined by end user.
Gene symbol	KLRB1
Gene Fullname	killer cell lectin like receptor B1
Product format	Liquid. PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Reconstitution and storage	2°C to 8°C\|-20°C
Description of target	Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1, 3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
Nucleotide accession_num	NM_002258
Protein accession_num	NP_002249.1
Protein name	Killer cell lectin-like receptor subfamily B member 1
Clonality	Polyclonal
Purification	Affinity Purified; Protein A Purified
Immunogen	Range: Lys73 - Ser188
Manufacturer - Specificity	The antibody is a rabbit polyclonal antibody raised against KLRB1. It has been selected for its ability to recognize KLRB1 in immunohistochemical staining and western blotting.
Formulation	PBS, pH7.4, containing 0.02% NaN3, 50% glycerol
Concentration	0.5 mg/ml

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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OACD05024-datasheet.pdf

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Amount: 100 ul

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Delivery expected until 1/8/2026

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