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CD130 Antibody

CD130 Antibody

Item no.	OADB00052
Manufacturer	AVIVA Systems Biology
Amount	200 ug
Category	Oncology Neuroscience Neural Lineage Markers Neuroinflammation Metabolism Diabetes Glucose Homeostasis Regulation of Appetite Molecular Targets for Neuroscience Neural Signaling Antibodies By Cell Type Carcinoma Hematology Leukemia Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Flow Cytometry Immunoprecipitation Western Blot Primary Antibodies Glial Cell Markers
Type	Antibody Monoclonal
Format	Lyophilized
Applications	WB, FC, IP
Clone	B-S12
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1
Citations	Ancey, C. et al., Cytokine,2002; 18(4): 199-205. Ancey, C. et al.,Cardiovasc Res.,2003; 59(1): 78-85. Autissier, P. et al., Int Immunol.,1998; 10(12): 1881-9. Fourcin, M. et al., J Biol Chem.,1996; 271(20): 11756-60. Giese B. et al., J. Biol. Chem., 2003; 278 : 39205 - 39213 Gu, Z. J. et al.,Leukemia,2000; 14(1): 188-97. Hammacher, A. et al., J Biol Chem.,1998; 273(35): 22701-7. Hammacher, A. et al.,Biochem,2000; J 345 Pt 1: 25-32. Horsten, U. et al.,J Biol Chem.,1997; 272(38): 23748-57. Jover, R. et al., Faseb J.,2002; 16(13): 1799-801. Kallen, K. J. et al.,J Biol Chem.,1999; 274(17): 11859-67. Kube D. et al., Blood, 2001; 98 : 762 - 770 Kurth, I. et al., J Immunol.,1999; 162(3): 1480-7. Kurth, I. et al.,J Immunol.,2000; 164(1): 273-82. Lebeau, B. et al.,FEBS Lett.,1997; 407(2): 141-7. MÃ¼ller-Newen G. et al., J. Biol. Chem., 2000; 275 (7) : 4578 - 4586 Olivier, C. et al., J Biol Chem.,2000; 275(8): 5648-56. Puthier, D. et al.,Blood,1996; 88(12): 4659-66. Rebouissou C. et al., Blood, 1998; 91(12) : 4727 - 4737 Selander K.S. et al., Cancer Res., 2004; 64(19): 6924 - 6933 Simpson, R. J. et al.,Protein Sci.,1997; 6(5): 929-55. Thiel, S. et al.,Biochem,1998; J 330 (Pt 1): 47-54. Voisin M-B. et al., J. Biol. Chem., 2002; 277(16) : 13682 - 13692 Wang, Y. D. et al., Int Immunol.,2002; 14(6): 599-603. Wijdenes J. et al., Eur. J. Immunol., 1995; 25(12): 3474-81
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	CD130,GP130,HIES4,CDW130,IL-6RB,sGP130
Shipping Condition	Cool pack
Available
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Category	Root Catalog/Products/Monoclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Molecular Weight	104 kDa
Gene symbol	CD130
Gene Fullname	interleukin 6 signal transducer
Product format	Lyophilized
Reconstitution and storage	Stable at +2-8C for 12 months. For longer storage, freeze aliquots
Description of target	The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17.
Nucleotide accession_num	NM_001190981.1
Protein accession_num	NP_001177910.1
Protein name	interleukin-6 receptor subunit beta
Clonality	Monoclonal
Purification	Ion exchange chromatography
Manufacturer - Specificity	Recognises the Gp130, common subunit for IL-6, IL-11, OSM, LIF, CNTF, CT-1 receptors, a 130-140 kDa protein
Biological activity	Activates cells carrying gp130, Induces gp130 activation, Jak 1, Jak 2, Stat 1 and Stat 3 phosphorylation, Recognises the soluble antigen
Formulation	Phosphate-buffered saline. Sterile-filtered through 0.22 um and treated to remove endotoxins. Carrier and preservative free
Concentration	1 ug/uL
Storage Buffer	Phosphate-buffered saline. Sterile-filtered through 0.22 um and treated to remove endotoxins. Carrier and preservative free

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 200 ug

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Delivery expected until 11/27/2025

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