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IL-10 Antibody

IL-10 Antibody

Item no.	OADB00314
Manufacturer	AVIVA Systems Biology
Amount	500 ug
Category	Neuroscience Neural Lineage Markers Neuroinflammation Molecular Targets for Neuroscience Neural Signaling Antibodies Cell Biology Cell Culture Cytokines Immunohistochemistry Immunoprecipitation Western Blot ELISA Blocking Primary Antibodies Neuronal Cell Markers
Type	Antibody Monoclonal
Format	Lyophilized
Applications	Blocking
Clone	B-S10
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1
Citations	Balashov, K. E. et al., Neurology,2000; 55(2): 192-8. Brok, H. P. et al., J Immunol.,2002; 169(11): 6554-63. Debili, N.et al. Blood,2001; 97(7): 2023-2030. Egeler, R. M. et al., Blood,1999; 94(12): 4195-201. Fontana, S. et al., Blood,2003; 102(12): 4099-106. Jarry, A. et al., J. Clin. Invest., 2008;118(3):1132-42 Lelievre, E. et al., Cytokine,1998; 10(11): 831-40. Naji, A. et al., Blood,2007;110(12):3936-48 Ravirajan C.T. et al., 2004; 43(4) : 442 - 447 Schandene, L. et al., J Immunol.,1994; 152(9): 4368-74. Schrijver, I. A. et al., Brain,2001; 124(Pt 8): 1544-54. Villoslada, P. et al.,J Exp Med.,2000; 191(10): 1799-806.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	CSIF,TGIF,GVHDS,IL-10,IL10A
Shipping Condition	Cool pack
Available
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Category	Root Catalog/Products/Monoclonal Antibodies, Root Catalog/Products/Primary Antibodies
Manufacturer - Isotype	Mouse IgG1
Shipping Temperature	Wet Ice
Molecular Weight	21 kDa
Gene symbol	IL-10
Gene Fullname	interleukin 10
Product format	Lyophilized
Reconstitution and storage	Store at +2-8C for 12 months. For longer storage, freeze aliquots
Description of target	The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
Nucleotide accession_num	NM_000572.2
Protein accession_num	NP_000563.1
Protein name	interleukin-10
Clonality	Monoclonal
Purification	Ion exchange chromatography
Manufacturer - Specificity	Recognises both natural and recombinant human IL-10
Biological activity	Blocks IL-10 induced proliferation on MC/9 cell line
Formulation	Phosphate-buffered saline. Sterile-filtered through 0.22 um and treated to remove endotoxins. Carrier and preservative free
Concentration	1 ug/uL
Storage Buffer	Phosphate-buffered saline. Sterile-filtered through 0.22 um and treated to remove endotoxins. Carrier and preservative free

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 ug

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Delivery expected until 12/25/2025

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