EPHB4 Antibody (OAEC04289)

EPHB4

2050

EPH receptor B4 (EphB4), with 987-amino acid protein (about 108kDa), belongs to the ephrin receptor subfamily of the protein-tyrosine kinase fam ily. The Eph receptor tyros ine kinases and their ligands, the ephrins, regulate numerous biological processes in developing and adult tissues and have been implicated in cancer progression and in pathological forms of angiogenesis. EphB4 acts as a negative regulator of blood vessel branching and vas cular network formation, switching the vas cularization program from sprouting angiogenesis to circumferential vessel growth. EphB4 and its ligand ephrinB2 expres s in several kinds of tum or cells and correlate with tumorigenesis. EphB4 is thus a potential candidate as a predictor of disease outcome in several kinds of tumor and as target for novel therapy.

Purified recombinant fragment of EphB4 expressed in EColi.