EPHB4 Antibody (OAEC04409)

108 kDa

2050

EphB4. EPH receptor B4. Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system . Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycos ylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph fam ily of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyros ine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vas cular development.

Purified recombinant fragment of EphB4 (aa562-612)expressed in EColi.