AGT Antibody (OAEC04522)

Wet Ice

Ascitic fluid containing 0.03% sodium azide

AGT, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzym e renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzym e (ACE) to generate the phys iologically active enzym e angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dys genesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.

Purified recombinant fragment of human AGT expres sed in EColi.