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CD33 Antibody

CD33 Antibody

Item no.	OAEE00212
Manufacturer	AVIVA Systems Biology
Amount	0.1 mg (C100)
Category	Oncology Neuroscience Neuroinflammation Antibodies By Cell Type Hematology Leukemia Myeloma Flow Cytometry Western Blot Primary Antibodies
Type	Antibody Monoclonal
Applications	FC
Clone	HIM3-4
Specific against	Human (Homo sapiens), Primate
Host	Mouse
Isotype	IgG1
Conjugate/Tag	Biotin
Citations	McCormack E, Mujic M, Osdal T, Bruserud O, Gjertsen BT: Multiplexed mAbs: a new strategy in preclinical time-domain imaging of acute myeloid leukemia. Blood. 2013 Feb 14;121(7):e34-42. doi: 10.1182/blood-2012-05-429555. Leukocyte Typing VI., Kishimoto T. et al. (Eds.), Garland Publishing Inc. (1997). Leukocyte Typing V., Schlossman S. et al. (Eds.), Oxford University Press (1995). Orr SJ, Morgan NM, Elliott J, Burrows JF, Scott CJ, McVicar DW, Johnston JA: CD33 responses are blocked by SOCS3 through accelerated proteasomal-mediatedturnover. Blood. 2007 Feb 1;109(3):1061-8. Walter RB, HÃ¤usermann P, Raden BW, Teckchandani AM, Kamikura DM, Bernstein ID, Cooper JA: Phosphorylated ITIMs Enable Ubiquitylation of an Inhibitory Cell Surface Receptor. Traffic. 2007 Dec 18 Ulyanova T, Blasioli J, Woodford-Thomas TA, Thomas ML: The sialoadhesin CD33 is a myeloid-specific inhibitory receptor. Eur J Immunol. 1999 Nov;29(11):3440-9.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	CD33 antigen (gp67);CD33 molecule transcript;gp67;myeloid cell surface antigen CD33;p67;sialic acid-binding Ig-like lectin 3;SIGLEC3;SIGLEC-3.
Shipping Condition	Cool pack
Available
Specificity	Human, Non-human Primate
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Category	Root Catalog/Products/Monoclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	CD33
Gene Fullname	CD33 molecule
Product format	Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Reconstitution and storage	2°C to 8°C
Description of target	Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2, 6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).
Nucleotide accession_num	NM_001082618.1; NM_001177608.1; NM_001772.3
Protein accession_num	NP_001076087.1; NP_001171079.1; NP_001763.3
Protein name	Myeloid cell surface antigen CD33
Clonality	Monoclonal
Purification	Purified by size-exclusion chromatography
Immunogen	NFMY-9s human cell line
Manufacturer - Specificity	The antibody HIM3-4 reacts with CD33, a 67 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells; it is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells. HLDA V; WS Code M MA112 HLDA VI; WS Code M MA47
Formulation	Biotin
Concentration	1 mg/ml
Storage Buffer	Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg (C100)

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