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CD28 Antibody

CD28 Antibody

Item no.	OAEE00776
Manufacturer	AVIVA Systems Biology
Amount	0.1 mg (C100)
Category	Oncology Neuroscience Neuroinflammation Aging & Neurological Disorders Antibodies By Cell Type Carcinoma Hematology Leukemia Lymphoma Cell Biology Cell Culture Cytokines Flow Cytometry Immunoprecipitation Primary Antibodies
Type	Antibody Monoclonal
Applications	FC
Clone	JJ319
Specific against	Rat (Rattus norvegicus)
Host	Mouse
Isotype	IgG1
Conjugate/Tag	PE
Citations	Guillonneau C, SÃ©veno C, Dugast AS, Li XL, Renaudin K, Haspot F, Usal C, Veziers J, Anegon I, Vanhove B: Anti-CD28 antibodies modify regulatory mechanisms and reinforce tolerance in CD40Ig-treated heart allograft recipients. J Immunol. 2007 Dec 15;179(12):8164-71. Kerstan A, Armbruster N, Leverkus M, HÃ¼nig T: Cyclosporin A abolishes CD28-mediated resistance to CD95-induced apoptosis via superinduction of caspase-3. J Immunol. 2006 Dec 1;177(11):7689-97. van den Brandt J, Wang D, Reichardt HM: Resistance of single-positive thymocytes to glucocorticoid-induced apoptosis is mediated by CD28 signaling. Mol Endocrinol. 2004 Mar;18(3):687-95. Laskowski IA, Pratschke J, Wilhelm MJ, Dong VM, Beato F, Taal M, Gasser M, Hancock WW, Sayegh MH, Tilney NL: Anti-CD28 monoclonal antibody therapy prevents chronic rejection of renal allografts in rats. J Am Soc Nephrol. 2002 Feb;13(2):519-27. LÃ¼hder F, Huang Y, Dennehy KM, Guntermann C, MÃ¼ller I, Winkler E, Kerkau T, Ikemizu S, Davis SJ, Hanke T, HÃ¼nig T: Topological requirements and signaling properties of T cell-activating, anti-CD28 antibody superagonists. J Exp Med. 2003 Apr 21;197(8):955-66. Dengler TJ, Szabo G, Sido B, Nottmeyer W, Zimmerman R, Vahl CF, HÃ¼nig T, Meuer SC: Prolonged allograft survival but no tolerance induction by modulating CD28 antibody JJ319 after high-responder rat heart transplantation. Transplantation. 1999 Feb 15;67(3):392-8. Haspot F, Villemain F, Laflamme G, Coulon F, Olive D, Tiollier J, Soulillou JP, Vanhove B: Differential effect of CD28 versus B7 blockade on direct pathway of allorecognition and self-restricted responses. Blood. 2002 Mar 15;99(6):2228-34. Robinson LE, Clandinin MT, Field CJ: R3230AC rat mammary tumor and dietary long-chain (n-3) fatty acids change immune cell composition and function during mitogen activation. J Nutr. 2001 Jul;131(7):2021-7. Tacke M, Hanke G, Hanke T, HÃ¼nig T: CD28-mediated induction of proliferation in resting T cells in vitro and in vivo without engagement of the T cell receptor: evidence for functionally distinct forms of CD28. Eur J Immunol. 1997 Jan;27(1):239-47. And many other.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	CD28 antigen;CD28RNA;T-cell-specific surface glycoprotein CD28.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Category	Root Catalog/Products/Monoclonal Antibodies, Root Catalog/Products/Primary Antibodies
Manufacturer - Conjugate / Tag	R-PE
Shipping Temperature	Wet Ice
Gene symbol	Cd28
Gene Fullname	Cd28 molecule
Product format	Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Reconstitution and storage	2°C to 8°C
Description of target	Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation.
Nucleotide accession_num	NM_001243077.1; NM_001243078.1; NM_006139.3
Protein accession_num	NP_001230006.1; NP_001230007.1; NP_006130.1
Protein name	T-cell-specific surface glycoprotein CD28
Clonality	Monoclonal
Purification	Purified by size-exclusion chromatography
Immunogen	Mouse A20J B lymphoma cells transfected with rat CD28
Manufacturer - Specificity	The mouse monoclonal antibody JJ319 reacts with CD28, a disulfide-linked homodimeric type I glycoprotein (monomer of Mw 44 kDa) which is a critical costimulatory receptor of T cells.
Formulation	PE
Concentration	0.5 mg/ml
Storage Buffer	Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg (C100)

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Delivery expected until 12/25/2025

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