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ITGA2B Antibody

ITGA2B Antibody

Item no.	OAEE00860
Manufacturer	AVIVA Systems Biology
Amount	0.1 mg (C100)
Category	Neuroscience Neural Adhesion Molecules Antibodies Flow Cytometry Immunohistochemistry Immunoprecipitation Primary Antibodies
Type	Antibody Monoclonal
Applications	FC
Clone	MWReg30
Specific against	Mouse (Murine, Mus musculus)
Host	Rat
Isotype	IgG1
Conjugate/Tag	PE
Citations	Ramsey H, Zhang Q, Brown DE, Steensma DP, Lin CP, Wu MX: Stress-induced hematopoietic failure in the absence of immediate early response gene X-1. Haematologica. 2013 Sep 20. [Epub ahead of print] Sullivan BP, Wang R, Tawfik O, Luyendyk JP: Protective and damaging effects of platelets in acute cholestatic liver injury revealed by depletion and inhibition strategies. Toxicol Sci. 2010 May;115(1):286-94. Boisset JC, Clapes T, Van Der Linden R, Dzierzak E, Robin C: Integrin alphaIIb (CD41) plays a role in the maintenance of hematopoietic stem cell activity in the mouse embryonic aorta. Biol Open. 2013 Apr 11;2(5):525-32. Brancaleone V, Gobbetti T, Cenac N, le Faouder P, Colom B, Flower RJ, Vergnolle N, Nourshargh S, Perretti M: A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation. Blood. 2013 Jul 25;122(4):608-17.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	AI172977;al;alpha IIb;alphaIIb;CD41;CD41B;Gp;GP IIb;GPalpha IIb;GpIIb;integrin alpha-IIb;platelet glycoprotein IIb of IIb/II Ia complex;platelet membrane glycoprotein IIb.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Category	Root Catalog/Products/Monoclonal Antibodies, Root Catalog/Products/Primary Antibodies
Manufacturer - Conjugate / Tag	R-PE
Shipping Temperature	Wet Ice
Gene symbol	Itga2b
Gene Fullname	integrin alpha 2b
Product format	Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Reconstitution and storage	2°C to 8°C
Description of target	Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
Nucleotide accession_num	NM_000419.3
Protein accession_num	NP_000410.2
Protein name	Integrin alpha-IIb
Clonality	Monoclonal
Purification	Purified by size-exclusion chromatography
Immunogen	Murine platelets
Manufacturer - Specificity	The rat monoclonal antibody MWReg30 recognizes CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains GPIIb alpha (heavy chain; 120 kDa) and GPIIb beta (light chain; 23 kDa). CD41 is mainly expressed on platelets and megakaryocytes.
Formulation	PE
Concentration	0.5 mg/ml
Storage Buffer	Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg (C100)

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