Rabbit antibody to AQP4

FUNCTION: Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system. It is expressed predominantly in the ependymal cell lining the aqueductal system and over the space of the brain in contact with the subarachnoid space, as cerebrospinal fluid fills these structures it may facilitate water balance between brain parenchyma and the fluid compartment. In the plasma membranes of the neurons of the paraventricular and supraoptic nuclei, it may mediate rapid changes in cell volume in response to local shifts in extracellular osmolarity.
Tissue specificity: Abundant in mature brain but only weakly detectable in eye, kidney, intestine, and lung.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein

IHC, WB. A dilution of 1 : 1000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

12 months after reconstitution

1. Zelenin S, et al. Pediatr. Res. 48:335-339(2000)

A synthetic peptide from mouse AQP4 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat.

http://www.uniprot.org/uniprot/P55088
http://www.uniprot.org/uniprot/P47863

Polyclonal

Lyophilised