Rabbit antibody to ABCG2

FUNCTION: Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.
Subcellular location: Cell membrane; Multi-pass membrane protein
Tissue specificity: Highly expressed in placenta. Low expression in small intestine, liver and colon.

IHC, WB. A dilution of 1 : 1000 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

12 months after reconstitution

1. Zhou S, et al. Nat. Med. 7:1028-1034(2001)

A synthetic peptide from human ABCG1 conjugated to blue carrier protein was used as the antigen.

http://www.uniprot.org/uniprot/Q9UNQ0
http://www.uniprot.org/uniprot/F7B5F8
http://www.uniprot.org/uniprot/Q80W57
http://www.uniprot.org/uniprot/Q7TMS5

Polyclonal

Lyophilised