Rabbit antibody to AMPA2

FUNCTION: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.
Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction a€C synapse a€C postsynaptic cell membrane; Multi-pass membrane protein.
Tissue specificity: Detected in brain cortex, hippocampus and cerebellum (at protein level). Detected in hippocampus.

IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

12 months after reconstitution

1. Koehler M, et al. J. Biol. Chem. 269:17367-17370(1994)

A synthetic peptide from human AMPA2 conjugated to blue carrier protein was used as the antigen.

http://www.uniprot.org/uniprot/P23819
http://www.uniprot.org/uniprot/P42262
http://www.uniprot.org/uniprot/P19491

Polyclonal

Lyophilised