Rabbit antibody to KCNH2 (1120-1162)

Function: Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr).
Subcellular location: Membrane; Multi-pass membrane protein
Tissue specificity: Highly expressed in brain and testis, slightly less so in heart, adrenal, retina and thymus. Detected at lower levels in lung, soleus, tibialis, and at very low levels in cornea and lens. A shorter transcript is detected in skeletal muscle. Found in pituitary.

IHC, WB. A dilution of 1 : 1000 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

12 months after reconstitution

1. London B, et al. Circ. Res. 81:870-878(1997)
2. Crociani O, et al. J. Biol. Chem. 278:2947-2955(2003)

A synthetic peptide from aa region 1120-1162 of mouse KCNH2 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and human.

http://www.uniprot.org/uniprot/Q12809
http://www.uniprot.org/uniprot/O08962
http://www.uniprot.org/uniprot/O35219

Polyclonal

Lyophilised