Rabbit antibody to Tyrosine Hydroxylase (30-100)

Function: Plays an important role in the physiology of adrenergic neurons.
Defects in TH are the cause of dystonia DOPA-responsive autosomal recessive (ARDRD); also known as autosomal recessive Segawa syndrome. ARDRD is a form of DOPA-responsive dystonia presenting in infancy or early childhood. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Some cases of ARDRD present with parkinsonian symptoms in infancy. Unlike all other forms of dystonia, it is an eminently treatable condition, due to a favorable response to L-DOPA.
Subcellular location: Nucleus. Cytoplasm
Tissue specificity: Mainly expressed in the brain and adrenal glands.

IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

12 months after reconstitution

1. Kaneda N, et al. Biochem. Biophys. Res. Commun. 146:971-975(1987)
2. Grima B, et al. Nature 326:707-711(1987)

A synthetic peptide from aa region 30-100 of human Tyrosine Hydroxylase conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat and mouse.

http://www.uniprot.org/uniprot/P07101
http://www.uniprot.org/uniprot/P04177
http://www.uniprot.org/uniprot/P24529

Polyclonal

Lyophilised