IRAK Antibody

blue ice or room temperature

Predicted: 77kD
Observed: 77 kD

IRAK Antibody: Nuclear factor kappa B (NF-κ B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κ B mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFα and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently. IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. IRAK mediates a signaling cascade leading to NF-κ B activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF).

IRAK Antibody is affinity chromatography purified via peptide column.

PRS-1201-0.1mg

PRS-1220-0.1mg

IRAK Antibody is supplied in PBS containing 0.02% sodium azide.

At least four isoforms of IRAK are known to exist; this antibody will detect all four isoforms. IRAK antibody is predicted to not cross-react with other members of the IRAK protein family.

Polyclonal

Homo sapiens