SIRP alpha Antibody

blue ice or room temperature

75 - 110 kDa

SIRP alpha Antibody: Protein tyrosine phosphatases (PTPases) SHP-1 and SHP-2 are critical regulators in the intracellular signaling pathways that result in cell responses such as mitosis, differentiation, migration, survival, transformation or death. SHP-2 is a signal transducer for several receptor tyrosine kinases and cytokine receptors. A novel SHP-2 associated glycoprotein was recently cloned from human, rat, mouse and cattle by several labs and was designated SIRPalpha, SHPS-1, MyD-1, BIT and p84. SIRPalpha is a new gene family containing at least fifteen members. SIRPalpha is a substrate of many activated tyrosine kinases such as insulin receptor, EGFR, PDGFR and src, and a specific docking protein for SHP-2. SIRPalpha has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion and plays a general role in different physiological and pathological processes.

SIRP alpha Antibody is affinity chromatography purified via peptide column.

PRS-17-008-1pack

SIRP alpha Antibody is supplied in PBS containing 0.02% sodium azide.

SIRP alpha antibody was raised against a peptide corresponding to 17 amino acids near the carboxy terminus of human SIRP alpha 1.

The immunogen is located within the last 50 amino acids of SIRP alpha.

signal-regulatory protein alpha

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.