ASK1 Antibody

blue ice or room temperature

155 kDa

ASK1 Antibody: Mitogen-activated protein (MAP) kinase cascades are activated in response to various extracellular stimuli, including cytokines, growth factors and environmental stresses. A novel MAP kinase kinase kinase (MAPKKK) was recently identified and designated ASK1 (for apoptosis signal-regulating kinase 1) and MAPKKK5. ASK1 activated two different subgroups of MAPKK, MKK4 and MKK6, which in turn activated c-Jun N-terminal kinase (JNK) and p38 MAP kinase, respectively. ASK1/MAPKKK5 is activated by TNFR and Fas through the interaction with members of the TRAF family and Fas-associated protein Daxx. Overexpression of ASK1 induced apoptotic cell death, and a catalytically inactive form of ASK1 inhibited TNF-α -induced apoptosis. ASK1 is expressed in variety of human and mouse tissues.

ASK1 Antibody is affinity chromatography purified via peptide column.

PRS-17-002-1pack

ASK1 Antibody is supplied in PBS containing 0.02% sodium azide.

ASK1 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human ASK1.

The sequence is different from that of mouse by last two amino acids.

The immunogen is located within the last 50 amino acids of ASK1.

mitogen-activated protein kinase kinase kinase 5

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.