AGT Antibody

Apoptosis, Cancer, Cell Cycle

WB: 1:500 - 1:2000

IHC: 1:50 - 1:100

IF: 1:50 - 1:100

Observed: 53kDa

Polyclonal

Unconjugated

Store at -20˚ C. Avoid freeze / thaw cycles.

None

183

AGT

Homo sapiens

The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.

Immunohistochemistry of paraffin-embedded human liver cancer using AGT antibody (16-155) at dilution of 1:100 (40x lens).