IRAK-2 Antibody

Blue Ice

65 kDa

IRAK-2 Antibody: The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-κ B, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK2. Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-κ B activation. IRAKs also associate with Toll like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-κ B activation. Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory response. IRAK2 is expressed in a variety of human tissues.

Trial Size

2653876

PRS-1201-0.1mg

PRS-17-001-1pack

IRAK-2 Antibody is supplied in PBS containing 0.02% sodium azide.

Predicted species reactivity based on immunogen sequence: Mouse: (77%)

IRAK2 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human IRAK2.

The immunogen is located within amino acids 530 - 580 of IRAK-2.

interleukin-1 receptor-associated kinase 2

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.