BAFF Antibody

Blue Ice

Predicted: 31kD
Observed: 35 kD

BAFF Antibody: Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF (for B cell Activating Factor belonging to the TNF Family), BLyS (for B Lymphocyte Stimulator), TALL-1 (for TNF- and ApoL-related Leukocyte-expressed Ligand), and THANK (for TNF Homologue that Activate Apoptosis, NF-κ B and c-jun N-terminal Kinase). BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. Three receptors for BAFF were recently identified and designated TACI, BCMA and BAFF-R. BAFF and its receptors are essential for B cell development, survival, and humoral immune responses. BAFF is involved in the development of autoimmune diseases including systemic lupus erythaematosus and rheumatoid arthritis.

Trial Size

5730097

Human BAFF has 3 isoforms, including isoform 1 (285aa, 31kD), isoform 2 (266aa, 29kD) and isoform 3 (164aa, 17.6kD). Mouse BAFF has 2 isoforms, including isoform 1 (309aa, 34kD) and isoform 2 (290aa, 32kD). Rat BAFF has only one isoform (274aa, 30kD). 2221 can detect two longer human isoforms, mouse and rat.

PRS-1209-0.1mg

PRS-17-009-1pack

BAFF Antibody is supplied in PBS containing 0.02% sodium azide.

Anti-BAFF antibody (2221) was raised against a peptide corresponding to 16 amino acids near the carboxy terminus of human BAFF.

The immunogen is located within the last 50 amino acids of BAFF.

tumor necrosis factor (ligand) superfamily, member 13b

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.