Survivin Antibody

Blue Ice

Predicted: 17kD
Observed: 17 kD

Survivin Antibody: Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel IAP protein was recently identified and designated survivin, apoptosis inhibitor 4 (API4), and TIAP. Survivin/TIAP interacted with the processed form of caspase-3 and inhibited its proteolytic activity. Survivin/TIAP is predominantly expressed in tissues of embryos, transformed cell lines, and many human cancers and lymphomas.

Trial Size, IAV

59859878

Human Survivin has 7 isoforms, including isoform 1 (142aa, 16kD), isoform 2 (165aa, 19kD), isoform 3 (137aa, 16kD), isoform 4 (120aa, 14kD), isoform 5 (117aa, 14kD), isoform 6 (78aa, 9kD) and isoform 7 (74aa, 8.5kD). Mouse Survivin has 3 isoforms, including isoform 1 (140aa, 16kD), isoform 2 (121aa, 14kD) and isoform 3 (40aa, 4.7kD). Rat Survivin has one isoform (142aa, 17kD). 2233 can detect human and mouse.

PRS-1206-0.1mg

PRS-17-005-1pack

PRS-1204-0.1mg

1 mg/mL

WB: 1-5μ g/mL; ICC: 5 μ g/mL; IF: 20 μ g/mL; IHC: 5 μ g/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples; Immunofluorescence and Immunohistochemistry in mouse samples. All other applications and species not yet tested.

Anti-Survivin antibody (2233) was raised against a peptide corresponding to 12 amino acids near the amino terminus of human Survivin.

The immunogen is located within the first 50 amino acids of Survivin.

baculoviral IAP repeat-containing 5

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.