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Comparison

Acinus Antibody

Item no. PRS-2241-0.02mg
Manufacturer ProSci
Amount 0.02 mg
Quantity options 0.02 mg 0.1 mg
Category
Type Antibody Polyclonal
Format Liquid
Applications WB, IF, ELISA
Specific against Human (Homo sapiens)
Host Rabbit
Isotype IgG
Conjugate/Tag Unconjugated
Citations Zamzami N, Kroemer G. Condensed matter in cell death. Nature 1999 ;401:127-8.
Sahara S, Aoto M, Eguchi Y, Imamoto N, Yoneda Y, Tsujimoto Y. Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation. Nature 1999 401:168-73.
NCBI ACIN1
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias Acinus Antibody: ACN,ACINUS,fSAP152,KIAA0670,Apoptotic chromatin condensation inducer in the nucleus,Acinus
Shipping Condition Cool pack
Available
Manufacturer - Type
Primary Antibodies
Shipping Temperature
Blue Ice
Storage Conditions
Acinus antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Molecular Weight
220 kDa
Manufacturer - Research Area
Apoptosis, Cancer
Background
Acinus Antibody: Chromatin condensation and nuclear fragmentation (CCNF) is the hallmark of apoptosis. CCNF is triggered by the activation of members of caspase family, caspase activated DNase (CAD/DFF40), and several novel proteins including AIF and CIDE. A new inducer of chromatin condensation was recently identified and designated Acinus (for apoptotic chromatin condensation inducer in the nucleus). Acinus is cleaved by caspase-3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed. Three different spliced forms of Acinus have been identified in human and mouse and designated AcinusL, AcinusS and AcinusS'.
By Type
Apoptosis, Cancer
Badges
Trial Size
Modifications
None
Protein Gi #
5931959
Purification
Acinus Antibody is affinity chromatography purified via peptide column.
Positive Control 1
PRS-1204-0.1mg
Concentration
1 mg/ml
Buffer
Acinus Antibody is supplied in PBS containing 0.02% sodium azide.
Application Note
Acinus antibody can be used for detection of acinus by Western blot at 1 μ g/mL. An approximate 220 kDa band can be detected. For immunofluorescence start at 20 μ g/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Homology
Predicted species reactivity based on immunogen sequence: Mouse: (100%)
Immunogen
Acinus antibody was raised against a 16 amino acid peptide near the carboxy terminus of human Acinus.

The immunogen is located within amino acids 980 - 1030 of Acinus.
Clonality
Polyclonal
NCBI Official Name
apoptotic chromatin condensation inducer 1
NCBI Organism
Homo sapiens
Disclaimer
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
User Note
Optimal dilutions for each application to be determined by the researcher.
Acinus Antibody
Acinus Antibody
Acinus Antibody
Acinus Antibody
Acinus Antibody
Acinus Antibody

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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