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Caspase-13 Antibody

Caspase-13 Antibody

Item no.	PRS-2245-0.02mg
Manufacturer	ProSci
Amount	0.02 mg
Quantity options	0.02 mg 0.1 mg
Category	Neuroscience Neural Signaling Antibodies Immunohistochemistry Western Blot ELISA Primary Antibodies
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, ELISA, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	Humke EW, Ni J, Dixit VM. ERICE, a novel FLICE-activatable caspase. J Biol Chem 1998;273:15702-7 (WD0500)
NCBI	CASP4
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Caspase-13 Antibody: CASP13,Caspase-13,Evolutionary related interleukin-1-beta-converting enzyme,CASP-13
Shipping Condition	Cool pack
Available
Manufacturer - Type	Primary Antibodies
Shipping Temperature	Blue Ice
Storage Conditions	Caspase-13 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Molecular Weight	43 kDa
Manufacturer - Research Area	Apoptosis, Cancer
Background	Caspase-13 Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death is finally caused by members of the caspase family of proteases and caspase activated DNases. A novel member in the caspase family was recently identified and designated ERICE (for Evolutionarily Related Interleukin-1 beta Converting Enzyme) and caspase-13. Caspase-13 belongs to the ICE subfamily of caspases. Overexpression of caspase-13 induces apoptosis. Caspase-13 was activated by caspase-8, which is a key enzyme in death receptor induced apoptosis. Caspase-13 is expressed in a variety of human tissues and cell lines.
By Type	Apoptosis, Cancer
Badges	Trial Size
Modifications	None
Protein Gi #	10720034
Purification	Caspase-13 Antibody is Ion exchange chromatography purified.
Positive Control 1	PRS-1209-0.1mg
Positive Control 2	PRS-1403-0.1mg
Positive Control 3	PRS-1463-0.1mg
Concentration	1 mg/ml
Buffer	Caspase-13 Antibody is supplied in PBS containing 0.02% sodium azide.
Application Note	Caspase-13 antibody can be used for detection of caspase-13 by Western blot at 1 μ g/mL. A 43 kDa band should be detected. Antibody can also be used for immunohistochemistry starting at 10 μ g/mL. Antibody validated: Western Blot in human, mouse, and rat samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.
Homology	Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Immunogen	Caspase-13 antibody was raised against a 15 amino acid peptide near the amino terminus of bovine Caspase-13. The immunogen is located within amino acids 80 - 130 of Caspase-13.
Clonality	Polyclonal
NCBI Official Name	caspase 4, apoptosis-related cysteine peptidase
NCBI Organism	Bos taurus
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
User Note	Optimal dilutions for each application to be determined by the researcher.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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