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Comparison

DC-SIGN Antibody

Item no. PRS-2349-0.02mg
Manufacturer ProSci
Amount 0.02 mg
Quantity options 0.02 mg 0.1 mg
Category
Type Antibody Polyclonal
Format Liquid
Applications WB, ELISA, IHC-P
Specific against Human (Homo sapiens)
Host Rabbit
Isotype IgG
Conjugate/Tag Unconjugated
Citations Geijtenbeek TB, Kwon DS, Torensma R, et al. DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. Cell 2000;100:587-97.
Pohlmann S, Baribaud F, Lee B, et al. RW. DC-SIGN interactions with human immunodeficiency virus type 1 and 2 and simian immunodeficiency virus. J. Virol. 2001; 75:4664-72.
Geijtenbeek TB, Torensma R, van Vliet SJ, et al. Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses. Cell 2000; 100:575-85.
Soilleux EJ, Barten R, and Trowsdale J. DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on 19p13. J. Immunol. 2000; 165:2937-42.
NCBI CD209
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias DC-SIGN Antibody: CDSIGN,CLEC4L,DC-SIGN,DC-SIGN1,CD209 antigen,C-type lectin domain family 4 member L
Shipping Condition Cool pack
Available
Manufacturer - Type
Primary Antibodies
Shipping Temperature
Blue Ice
Storage Conditions
DC-SIGN antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Molecular Weight
Predicted: 44 kDa
Observed: 47 kDa
Manufacturer - Research Area
Infectious Disease
Background
DC-SIGN Antibody: Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN. ICAM-3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.
By Type
Infectious Disease
Badges
Trial Size
Modifications
None
Protein Gi #
46396012
Purification
DC-SIGN Antibody is affinity chromatography purified via peptide column.
Positive Control 1
PRS-1309-0.1mg
Positive Control 2
PRS-1308-0.1mg
Positive Control 3
PRS-11-801-4um
Concentration
1 mg/mL
Buffer
DC-SIGN Antibody is supplied in PBS containing 0.02% sodium azide.
Application Note
DC-SIGN antibody can be used for detection of DC-SIGN by Western blot at 2 μ g/mL. Antibody can also be used for immunohistochemistry starting at 10 μ g/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
Homology
Predicted species reactivity based on immunogen sequence: Mouse: (76%)
Immunogen
DC-SIGN antibody was raised against a synthetic peptide corresponding to 17 amino acids near the center of human DC-SIGN.

The immunogen is located within amino acids 250 - 300 of DC-SIGN.
Clonality
Polyclonal
NCBI Official Name
CD209 molecule
NCBI Organism
Homo sapiens
Disclaimer
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
User Note
Optimal dilutions for each application to be determined by the researcher.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.02 mg
Available: In stock
available

Delivery expected until 11/6/2025 

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