p53R2 Antibody

Blue Ice

Predicted: 39 kDa
Observed: 43 kDa

p53R2 Antibody: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including p53R2, Chk2, p53AIP1, Noxa, PIDD, and PID/MTA2, were recently discovered. p53R2 is a p53 inducible gene that contains a p53 binding sequence and encodes a subunit of the enzyme ribonucleotide reductase. p53R2 is induced by the reagents, ultraviolet and gamma-irradiation that cause DNA damages. The product of p53R2 gene is directly involved in the p53 checkpoint for repair of damaged DNA. The isoform of the p53 family member p73 also induces p53R2 expression. p53R2 is an important target of p53 for tumor suppression.

Trial Size

7229086

PRS-1202-0.1mg

PRS-1302-0.1mg

1 mg/mL

p53R2 antibody can be used for detection of p53R2 by Western blot at 1 μ g/mL. Antibody can also be used for immunohistochemistry starting at 1 μ g/mL. For immunofluorescence start at 20 μ g/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

p53R2 antibody was raised against a 16 amino acid peptide near the amino terminus of human p53R2.

The immunogen is located within the first 50 amino acids of p53R2.

ribonucleotide reductase M2 B (TP53 inducible)

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.