Chk2 Antibody

Blue Ice

Predicted: 60 kDa
Observed: 60 kDa

Chk2 Antibody: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including Chk2, p53R2, p53AIP1, Noxa, PIDD, and PID/MTA2, were recently discovered. The checkpoint kinase Chk2 is the mammalian homologue of yeast Cds1/Rad53. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53. Chk2 serves as ATM downstream effector to mediate activation of p53. Chk2 also phosphorylates and activates BRCA1, the product of a tumor suppressor gene that is mutated in breast and ovarian cancer.

Trial Size

6005850

PRS-1205-0.1mg

PRS-17-005-1pack

Chk2 Antibody is supplied in PBS containing 0.02% sodium azide.

Chk2 antibody was raised against a synthetic peptide corresponding to amino acids near the amino terminus of human Chk2.

The immunogen is located within the first 50 amino acids of Chk2.

CHK2 checkpoint homolog (S. pombe)

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.