MTBP Antibody

Blue Ice

Predicted: 104 kDa
Observed: 104 kDa

MTBP Antibody: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 network, including Chk2, p53R2, p53AIP1, Noxa, PIDD, PID/MTA2 and MTBP, were recently discovered. The transcriptional activity of p53 is modulated by posttranslational regulations of the p53 protein including stabilization and acetylation. P53 transcriptionally activates MDM2 gene then the translated MDM2 protein binds to p53 and promotes the degradation of p53 leading to lowering the concentration of p53 protein. MDM2 inhibits both p53 mediated G1 arrest and apoptosis. A recently discovered protein termed MTBP was found to bind to MDM2 and to inhibit the modulation effect of MDM2 on p53. MTBP is expressed in a variety of normal tissues.

Trial Size

21630257

PRS-1204-0.1mg

1 mg/ml

MTBP antibody can be used for detection of MTBP by Western blot at 1 to 2 μ g/mL. A 104 kDa band can be detected. Antibody can also be used for immunocytochemistry starting at 5 μ g/mL. For immunofluorescence start at 20 μ g/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

MTBP antibody was raised against a 18 amino acid peptide near the center of human MTBP.

The immunogen is located within amino acids 110 - 160 of MTBP.

Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.